I am not a car expert. I am not a fuel expert. So I shall defer to the experts for this thrifty tip:
How to Save Money on Gas - 29 Tips
Tips from the FTC
30 Tips to Save on Gas
It may also be possible to convert your car to use less, or no, gasoline. I have no intimate knowledge of this but I'd love to hear, and share, your story if you've done this.
And what not to do (some of these are mentioned in the posts above, use your best judgement):
6 Ways to Not Save on Gas